HD-MEA
# 1細胞単位の活動解析、軸索伝導、伝播解析により メカニズムに迫ります。
数万～数十万の微小電極で構成されたHigh Density (HD)-MEAを用いて、1細胞単位の神経活動を分析します。1細胞単位の化合物応答、シナプス機能解析、軸索伝導解析より厳密なメカニズムの説明を可能とします。心筋細胞の伝導速度、伝導面積、起始点解析により、毒性検出が難しい化合物や作用機序予測を可能とします。
参考論文
Yuan X, Schröter M, Obien MEJ, Fiscella M1, Gong W, Kikuchi T, Odawara A, Noji S, Suzuki I, Takahashi J, Hierlemann A, Frey U. Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level. Nature communication. 2020 11(1):4854.DOI
Brain Slice
A.Hasegawa, N.Matsuda, I. Suzuki, "Development of a Microelectrode Array System for Simultaneous Measurement of Field Potential and Glutamate Release in Brain Slices" Biosens. Bioelectron., 287, 2025, 117696 DOI
H.Takahashi, N.Matsuda, I. Suzuki, “Analysis of β rhythm induction in acute brain slices using field potential imaging with UHD-CMOS-MEA” bioRxiv, 2025, DOI
I. Suzuki*, N. Matsuda, X. Han, S. Noji, M. Shibata, N. Nagafuku, Y. Ishibashi, Large-area field potential imaging having single neuron resolution using 236,880 electrodes CMOS-MEA technology, Advanced Science, 2023, 1-23 DOI
Cardiomyocytes
N. Matsuda, N.Nagafuku, K.Matsuda, Y.Ishibashi, T.Taniguchi, Y.Matsuchita, N.Miyamoto, T.Yoshinaga, I.Suzuki, “Field potential Imaging in human iPSC- derived Cardiomyocytes using UHD-CMOS-MEA” bioRxiv, 2025, DOI
M. Osawa, Y. Fujita, K. Kagami, M. Ito, Y. Tamura, S. Tateishi , J. Take, F. Hirose, H. Hagiwara, K.e Imai, D. Yoshinaga, S. Baba, M. Osawa, H. Harashima, K. Murayama, Y. Akioka, A. Ohtake I. Suzuki, T. Adachi, T. Yamazaki, S. Arai, S. Matsumoto, T. K. Megumu K. Saito, I. Ohsawa and S. Nonoyama, “Cardiac dysfunction due to mitochondrial impairment assessed by human iPS cells caused by DNM1L mutations” Pediatric Research, 2025, 1-14, DOI
